Cerebrospinal Fluid Homer-3 Autoantibodies in a Patient with Amnestic Mild Cognitive Impairment

Cerebrospinal Fluid Homer-3 Autoantibodies in a Patient with Amnestic Mild Cognitive Impairment

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(1) Background: Homer-3 antibodies are associated with cerebellar disease ranging from subacute degeneration to cerebellitis.However, cognitive impairment associated with Homer-3 autoantibodies has not been reported until now.(2) Methods: in retrospect, we systematically studied clinical, cranial magnetic resonance imaging (cMRI), electroencephalography (EEG) and lumbar puncture data, including neural autoantibodies of a clinical case.(3) Results: we describe the case of a 56-year-old woman presenting with amnestic mild cognitive read more impairment in association with serum and CSF detection of Homer-3 autoantibodies and a depressive syndrome.

cMRI revealed cerebellar atrophy.CSF analysis showed elevated ptau181 protein.Applying the criteria for an autoimmune psychiatric syndrome revealed a plausible autoimmune basis for the mild cognitive impairment.(4) Discussions: our case report demonstrates an amnestic mild cognitive impairment and depressive symptoms associated with Homer-3 autoantibodies read more as a novel feature of Homer-3 antibody-related disease.

We also propose that cognitive dysfunction might result from impaired AMPAR signaling in the hippocampus induced by Homer-3 antibodies, which will have to be verified in further research.